USMLE Step 2 CK topics by organ system
Every Step 2 CK topic, organized the way the exam tests it — by organ system. Explore 14 systems and 1,087 discrete topics, each paired with trap-aware practice questions that teach you why the wrong answers were written to fool you.
Cardiovascular
10 areas · 126 topicsArrhythmias, heart failure, ischemic disease, and valvular disorders — the highest-yield system on Step 2 CK.
Dermatology
6 areas · 55 topicsSkin emergencies, common rashes, and cutaneous manifestations of systemic disease.
Endocrine
10 areas · 46 topicsDiabetes, thyroid, adrenal, pituitary, and calcium disorders.
Gynecology
7 areas · 69 topicsMenstrual disorders, contraception, infections, and gynecologic oncology.
Gastrointestinal
10 areas · 108 topicsLuminal GI, hepatobiliary disease, pancreatitis, and the acute abdomen.
Hematology
8 areas · 90 topicsAnemias, thrombosis, bleeding disorders, and hematologic malignancy.
Infectious Disease
8 areas · 129 topicsEmpiric therapy, sepsis, antimicrobial selection, and high-yield pathogens.
Neurology
16 areas · 87 topicsStroke, seizure, headache, neuromuscular disease, and altered mental status.
Ophthalmology
1 areas · 36 topicsThe red eye, acute vision loss, and ocular emergencies.
Obstetrics
2 areas · 54 topicsPrenatal care, labor and delivery, and obstetric complications.
Psychiatry
10 areas · 81 topicsMood, psychotic, anxiety, and substance use disorders, plus psychopharmacology.
Pulmonary
9 areas · 67 topicsObstructive and restrictive disease, pulmonary embolism, infections, and critical-care respiratory management.
Renal
10 areas · 53 topicsAcid-base, electrolytes, AKI and CKD, glomerular disease, and stones.
Musculoskeletal
8 areas · 86 topicsOrthopedic emergencies, fractures, arthritides, and sports injuries.
Practice Step 2 CK the right way
280Bound doesn't just tell you the right answer — it reverse-engineers why the wrong ones were tempting, so you build reasoning that transfers to exam day.